Menopause & Andropause

LathMized™ NAD+
Menopause & Andropause Support

When oestrogen or testosterone decline, NAD+ follows. The fatigue that doesn't lift, the sleep that doesn't restore, the clarity that's gone slightly blunt — these aren't just hormonal symptoms. They're the downstream consequence of accelerated cellular energy loss. This protocol addresses that deficit at its source.

2-Phase Protocol Practitioner Supervised RCT-Backed Formula Members Only

Menopause & Andropause Support·2-Phase Protocol·Perimenopause Support·Andropause Support·Hormonal Energy·Sleep & Clarity·SIRT1 Activation·Practitioner Supervised·NCT07336836·Ships UK · EU · US · Canada·Menopause & Andropause Support·2-Phase Protocol·Perimenopause Support·Andropause Support·Hormonal Energy·Sleep & Clarity·SIRT1 Activation·Practitioner Supervised·NCT07336836·Ships UK · EU · US · Canada·

53^%

Intracellular NAD+
increase · 5 days

100^%

Participants
responded

32^%

SIRT1 longevity
protein increase

Serious adverse
events recorded

This protocol is designed for

Is this right for you?

You want to feel like yourself again — not a diminished version. You've accepted some changes but you haven't given up on energy, clarity and resilience. This protocol works at the cellular level of what's actually driving those changes.

You're tired in a way that sleep doesn't fix — and no amount of rest seems to restore you the way it used to. Hormonal decline accelerates NAD+ depletion, which directly impairs mitochondrial energy production at the cellular level.

Your sleep has changed — harder to fall asleep, harder to stay asleep, and you wake up unrefreshed. Declining NAD+ disrupts sirtuin signalling and circadian regulation, both of which govern sleep architecture.

Your thinking feels different — word retrieval, focus, mental sharpness. Hormonal transitions accelerate brain NAD+ depletion, impairing neuroprotective pathways and serotonin signalling. It's not psychological — it's biochemical.

You've used other NAD+ supplements without the effect you expected — standard oral NAD+, NMN and NR products face limited bioavailability through digestion and rely on precursor conversion pathways that are rate-limited and decline with age. LathMized™ is designed to support intracellular NAD+ levels directly via mucosal absorption, rather than relying on precursor conversion.

You want something that addresses the cellular cause, not just the symptoms — HRT or TRT addresses hormones directly. This protocol addresses the cellular energy deficit those hormonal changes drive. The two approaches are complementary.

What this protocol supports

Key clinical benefits

All claims are based on statistically significant biomarker changes from the RENEWAL-NAD+ placebo-controlled double-blind RCT (NCT07336836).

Cellular Energy Restoration

Hormonal decline accelerates NAD+ depletion, directly impairing mitochondrial ATP production. Phase 1 restores intracellular NAD+ by 53% in 5 days — addressing the cellular energy deficit at its root, not the symptoms it produces.

Cognitive Clarity & Mental Sharpness

The RENEWAL-NAD+ trial showed significant upregulation of neuroprotective proteins and serotonin signalling markers. The brain fog and word-retrieval difficulties associated with hormonal transition have a direct cellular basis — and a cellular solution.

Sleep Architecture Support

NAD+ is essential for sirtuin signalling and circadian regulation. As NAD+ is restored, the biological mechanisms that govern sleep quality — not just sleep onset — begin to function more effectively. Most members notice sleep changes in weeks 2 to 4.

SIRT1 Activation

SIRT1 — a key sirtuin protein that regulates cellular stress response, metabolic efficiency and inflammatory signalling — requires NAD+ as its cofactor. The RENEWAL-NAD+ trial confirmed a 32% increase in SIRT1 expression. This is core to the hormonal transition experience.

Oxidative Stress Defence

Hormonal transitions increase oxidative stress burden. The trial showed significant improvements in glutathione recycling and antioxidant enzyme function — directly addressing the cellular stress component of the hormonal experience.

Metabolic Resilience

Oestrogen and testosterone support metabolic regulation — their decline destabilises glucose handling, lipid metabolism and energy efficiency. Restoring NAD+ supports the downstream metabolic pathways that hormonal decline disrupts.

All benefits listed reflect statistically significant biomarker changes from the RENEWAL-NAD+ placebo-controlled double-blind RCT (NCT07336836) — conducted with the Institute of Systems Biology and published on bioRxiv 2026. Peer review pending.

Your membership includes

What you receive

Every element of this protocol — including the full dosing schedule, product supply and practitioner support — is available exclusively to Harmover members.

Practitioner Assessment

A Harmover practitioner reviews your hormonal health history, current medications and symptom picture before approving protocol access — including review of any HRT or TRT.

Full Protocol Access

Your complete 2-phase dosing schedule and administration guide — released in your member dashboard on approval. Includes monitoring guidance specific to hormonal transition.

LathMized™ NAD+ Products

Phase 1 powder for 15-day repletion and Phase 2 sublingual tablets for long-term daily maintenance — both shipped after purchase.

Ongoing Practitioner Support

Regular check-ins and practitioner messaging throughout the protocol — available via your member dashboard throughout both phases.

Purchase options

Get the products for this protocol

The Menopause & Andropause Support uses LathMized™ Powder for the first 15 days (Phase 1), then sublingual tablets for long-term daily maintenance (Phase 2). All products require member registration and practitioner approval.

Complete bundle Best Value

Complete Menopause & Andropause Kit

Powder + Tablets — both phases

Both phase products together — the Phase 1 powder for the 15-day repletion period and Phase 2 tablets for ongoing daily maintenance. Includes your full protocol document, monitoring guidance, and practitioner support.

Phase 1 Powder included Phase 2 Tablets included Practitioner support included

Free registration · No commitment

Or purchase by phase individually

Phase 1 · Repletion

LathMized™ NAD+ Powder

Used in Phase 1 of the Menopause & Andropause Support — 1,000mg daily for 15 days, dissolved in water and sipped in two divided doses. Mucosal absorption delivers NAD+ directly to cells.

Protocol dose

1,000mg/day · BID · 15 days

Phase 2 · Long-Term Maintenance

LathMized™ NAD+ Sublingual Tablets

Used in Phase 2 from Day 16 onwards — 100–200mg daily via one or two sublingual tablets placed under the tongue each morning and evening. Sustains cellular NAD+ levels long-term through hormonal transition.

Protocol dose

100–200mg/day · BID · Day 16+

Members only

Access this protocol
through Harmover

This protocol — including the full dosing schedule, phase-by-phase administration guide, and product supply — is available exclusively to registered Harmover members.

Registration is free and takes less than two minutes. Once registered, a Harmover practitioner will review your health summary before releasing your personalised protocol access.

Register free — create your Harmover member account with basic health information

Practitioner review — a qualified Harmover practitioner reviews your health summary and approves protocol access

Receive your protocol — full dosing schedule, products shipped, and practitioner support activated through your member dashboard

Menopause & Andropause

LathMized™ NAD+ Menopause & Andropause Support

Your membership includes

Practitioner-reviewed protocol access
Hormonal transition monitoring guidance
Phase-appropriate LathMized™ NAD+ products
Full dosing schedule & administration guide
Ongoing practitioner support & check-ins

Free to register · No commitment · Ships UK · EU · US · Canada

Clinical evidence

Backed by a double-blind RCT

The RENEWAL-NAD+ study — conducted with the Institute of Systems Biology, approved by Western IRB (Protocol No. 20215675) — provides the clinical foundation for the LathMized™ platform.

"LathMized™ NAD+ achieved a 53% increase in intracellular NAD+ concentration in 5 days — with blood plasma NAD+ remaining unchanged, confirming cellular rather than circulatory delivery. 100% of participants responded. SIRT1 increased by 32%. 9 of 12 hallmarks of ageing were positively impacted. Zero serious adverse events across 60 participants aged 45–75."

RENEWAL-NAD+ RCT · NCT07336836 · bioRxiv 2026 · DOI: 10.64898/2026.03.25.714130

RENEWAL-NAD+ RCT · NCT07336836 · bioRxiv 2026 Read preprint ↗ ClinicalTrials.gov ↗

53^%

Intracellular NAD+
increase · 5 days

Biomarkers
significantly changed

9/12

Hallmarks of ageing
positively impacted

Serious adverse
events recorded

Common questions

Questions about the Menopause & Andropause Support

Is this suitable for both menopause and andropause?

Yes — this protocol is designed for both. Menopause and andropause share a common metabolic picture: hormonal shifts accelerate NAD+ depletion, which compounds fatigue, cognitive changes and sleep disruption. The protocol addresses the underlying cellular deficit regardless of sex or hormonal profile.

Will this affect my hormone levels directly?

LathMized™ NAD+ does not modify hormone production. It addresses the cellular energy deficit that hormonal changes exacerbate — specifically the NAD+ depletion that impairs mitochondrial function, DNA repair and sirtuin activity. Improving the cellular environment often produces meaningful improvements in how hormonal changes feel day to day.

How does this differ from HRT or testosterone therapy?

HRT and TRT replace declining hormones directly. This protocol works at the cellular level, addressing the NAD+ deficit that hormonal transitions accelerate. The two approaches are complementary, and many members use this protocol alongside hormone therapy. Your practitioner will review your current care as part of the assessment.

How quickly will I notice a difference?

Most members notice shifts in energy and sleep within the first two weeks of Phase 1. Cognitive clarity typically improves in weeks 2 to 4. The changes build over 60 to 90 days as NAD+ levels stabilise and cellular function improves throughout hormonal transition.

Do I need to take this indefinitely?

Phase 2 is ongoing daily maintenance — one or two sublingual tablets each day. Because NAD+ levels decline with age and hormonal changes accelerate that decline, ongoing supplementation sustains the repletion achieved in Phase 1. Many members find it becomes a simple daily habit. You can pause at any time.

Is this safe alongside my existing supplements or HRT?

NAD+ supplementation at these doses is generally well-tolerated. The RENEWAL-NAD+ trial recorded zero serious adverse events. Your practitioner will review any current medications or supplements — including HRT or TRT — at the assessment stage. Please disclose everything during registration.

Is this a prescription product?

LathMized™ NAD+ is a dietary supplement — not a prescription product. No GP referral is needed to register. Harmover's practitioner review is built into membership to ensure this protocol is appropriate for your specific situation.

Important information

Before you begin

Please read

This is a wellness and nutritional programme — not a medical treatment for menopause, andropause or any hormonal condition. Please continue all consultations with your GP or specialist and ensure they know you are following this programme. If you are taking HRT, TRT, or other hormone-related medications, please disclose these during registration so your practitioner can review appropriately. NAD+ at these doses is generally well-tolerated, but your practitioner will confirm suitability for your specific situation.

Ready to begin?

Ready to address your hormonal health at the root?

Register free, go through your practitioner review, and receive your full hormonal support protocol. Meaningful cellular change builds over weeks and months — this is a long-term programme, not a quick fix.

Free to register · No commitment · Ships UK · EU · US · Canada

Reviewed by

Harmover Wellness Coach Team · April 2026

RENEWAL-NAD+ preprint ↗ ClinicalTrials.gov ↗ About our team ↗

LathMized™ NAD+Menopause & Andropause Support